The #1 seeded Duke Blue Devils(31-5) match up with the #4 seeded Purdue Boilmakers(29-5) in the South Regional semifinals tonight at Reliant Stadium in Houston, TX at 9:55PM EST(airs nationally on CBS). Duke coach Mike Krzyzewski will be trying to lead his program back to the Elite 8 for the 1st time in six years with a win tonight for a chance to earn a Final Four berth for the 1st time since 2004. Duke has lost to a lower-seeded opponent in the Sweet 16 round three out of the last five years and didn’t even get past the 1st two rounds in 2007 and 2008. Purdue, meanwhile, has never made a Final Four appearance since the field expanded to 64 teams in 1985 and have not made it to the Elite 8 round since an appearance in 2000. Purdue will be making their second straight Sweet 16 appearance but will be shorthanded after star forward Robbie Hummel was lost for the season with a knee injury in February. Vegas oddsmakers have made Duke the -8.5 point favorite with the total set at 126.5. NSAwins.com’s expert handicapper William E. Stockton likes Duke to win handily tonight and says to lay the -8.5 points. You can bet on tonight’s Purdue-Duke Sweet 16 game at SBG Global Sportsbook(30% SIGN UP BONUS) – NSAwins.com’s #1 sportsbook for March Madness Betting! View all of tonight’s updated NCAA Tournament Odds and Lines at NSAwins.com.